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What are the limits on the amount of pathogens that a body can be immune to at any given time?
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Before the seasonal flu vaccine was recommended for all healthy adults, people in developed countries might get vaccinated against on the order of 10 different pathogens and develop immunity for some more via natural exposure.
Now the same person is expected to take a seasonal flu vaccine for a new strain every year - won't this put them in an uncharted territory as far as effects on the immune systems are concerned within a couple of decades?
immune-system vaccination virology microbiology
edited 1 hour ago
Narusan
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Macrophagus
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up vote
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down vote
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Before the seasonal flu vaccine was recommended for all healthy adults, people in developed countries might get vaccinated against on the order of 10 different pathogens and develop immunity for some more via natural exposure.
Now the same person is expected to take a seasonal flu vaccine for a new strain every year - won't this put them in an uncharted territory as far as effects on the immune systems are concerned within a couple of decades?
immune-system vaccination virology microbiology
edited 1 hour ago
Narusan
4,83421540
asked 6 hours ago
Macrophagus
61
New contributor
Macrophagus is a new contributor to this site. Take care in asking for clarification, commenting, and answering.
Check out our Code of Conduct.
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up vote
1
down vote
favorite
up vote
1
down vote
favorite
Before the seasonal flu vaccine was recommended for all healthy adults, people in developed countries might get vaccinated against on the order of 10 different pathogens and develop immunity for some more via natural exposure.
Now the same person is expected to take a seasonal flu vaccine for a new strain every year - won't this put them in an uncharted territory as far as effects on the immune systems are concerned within a couple of decades?
immune-system vaccination virology microbiology
edited 1 hour ago
Narusan
4,83421540
asked 6 hours ago
Macrophagus
61
New contributor
Macrophagus is a new contributor to this site. Take care in asking for clarification, commenting, and answering.
Check out our Code of Conduct.
Before the seasonal flu vaccine was recommended for all healthy adults, people in developed countries might get vaccinated against on the order of 10 different pathogens and develop immunity for some more via natural exposure.
Now the same person is expected to take a seasonal flu vaccine for a new strain every year - won't this put them in an uncharted territory as far as effects on the immune systems are concerned within a couple of decades?
immune-system vaccination virology microbiology
immune-system vaccination virology microbiology
edited 1 hour ago
Narusan
4,83421540
asked 6 hours ago
Macrophagus
61
New contributor
Macrophagus is a new contributor to this site. Take care in asking for clarification, commenting, and answering.
Check out our Code of Conduct.
edited 1 hour ago
Narusan
4,83421540
asked 6 hours ago
Macrophagus
61
New contributor
Macrophagus is a new contributor to this site. Take care in asking for clarification, commenting, and answering.
Check out our Code of Conduct.
edited 1 hour ago
Narusan
4,83421540
edited 1 hour ago
Narusan
4,83421540
edited 1 hour ago
Narusan
4,83421540
4,83421540
asked 6 hours ago
Macrophagus
61
New contributor
Macrophagus is a new contributor to this site. Take care in asking for clarification, commenting, and answering.
Check out our Code of Conduct.
asked 6 hours ago
Macrophagus
61
asked 6 hours ago
Macrophagus
61
61
New contributor
Macrophagus is a new contributor to this site. Take care in asking for clarification, commenting, and answering.
Check out our Code of Conduct.
New contributor
Macrophagus is a new contributor to this site. Take care in asking for clarification, commenting, and answering.
Check out our Code of Conduct.
Macrophagus is a new contributor to this site. Take care in asking for clarification, commenting, and answering.
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1 Answer
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Won't this (having a flu vaccine every year) put them in an uncharted territory as far as effects on the immune systems are concerned within a couple of decades?
No
You are exposed to and develop a memory response to many, many more pathogens than vaccines. Your collective immune memory from natural exposure to a pathogen is much, much larger than from vaccination.
Effective vaccines reproduce the immune response of exposure to a pathogen (see the CDC pink book, Chapter 1), but use specific subgroups of antigens important for protective immunity. The number of vaccines you get is much smaller than the number of different antigens you are exposed to. Considering the common cold alone, the incidence in the US is 6 per person year for children, 2 per person year for adults without exposure to children (see Cecil Medicine Ch. 369). Each of these exposures involves many different antigens. Vaccine related immune memory is a drop in the bucket.
answered 4 hours ago
De Novo
60211
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1 Answer
1
active
oldest
votes
1 Answer
1
active
oldest
votes
active
oldest
votes
active
oldest
votes
up vote
5
down vote
Won't this (having a flu vaccine every year) put them in an uncharted territory as far as effects on the immune systems are concerned within a couple of decades?
No
You are exposed to and develop a memory response to many, many more pathogens than vaccines. Your collective immune memory from natural exposure to a pathogen is much, much larger than from vaccination.
Effective vaccines reproduce the immune response of exposure to a pathogen (see the CDC pink book, Chapter 1), but use specific subgroups of antigens important for protective immunity. The number of vaccines you get is much smaller than the number of different antigens you are exposed to. Considering the common cold alone, the incidence in the US is 6 per person year for children, 2 per person year for adults without exposure to children (see Cecil Medicine Ch. 369). Each of these exposures involves many different antigens. Vaccine related immune memory is a drop in the bucket.
answered 4 hours ago
De Novo
60211
add a comment |Â
up vote
5
down vote
Won't this (having a flu vaccine every year) put them in an uncharted territory as far as effects on the immune systems are concerned within a couple of decades?
No
You are exposed to and develop a memory response to many, many more pathogens than vaccines. Your collective immune memory from natural exposure to a pathogen is much, much larger than from vaccination.
Effective vaccines reproduce the immune response of exposure to a pathogen (see the CDC pink book, Chapter 1), but use specific subgroups of antigens important for protective immunity. The number of vaccines you get is much smaller than the number of different antigens you are exposed to. Considering the common cold alone, the incidence in the US is 6 per person year for children, 2 per person year for adults without exposure to children (see Cecil Medicine Ch. 369). Each of these exposures involves many different antigens. Vaccine related immune memory is a drop in the bucket.
answered 4 hours ago
De Novo
60211
add a comment |Â
up vote
5
down vote
up vote
5
down vote
Won't this (having a flu vaccine every year) put them in an uncharted territory as far as effects on the immune systems are concerned within a couple of decades?
No
You are exposed to and develop a memory response to many, many more pathogens than vaccines. Your collective immune memory from natural exposure to a pathogen is much, much larger than from vaccination.
Effective vaccines reproduce the immune response of exposure to a pathogen (see the CDC pink book, Chapter 1), but use specific subgroups of antigens important for protective immunity. The number of vaccines you get is much smaller than the number of different antigens you are exposed to. Considering the common cold alone, the incidence in the US is 6 per person year for children, 2 per person year for adults without exposure to children (see Cecil Medicine Ch. 369). Each of these exposures involves many different antigens. Vaccine related immune memory is a drop in the bucket.
answered 4 hours ago
De Novo
60211
Won't this (having a flu vaccine every year) put them in an uncharted territory as far as effects on the immune systems are concerned within a couple of decades?
No
You are exposed to and develop a memory response to many, many more pathogens than vaccines. Your collective immune memory from natural exposure to a pathogen is much, much larger than from vaccination.
Effective vaccines reproduce the immune response of exposure to a pathogen (see the CDC pink book, Chapter 1), but use specific subgroups of antigens important for protective immunity. The number of vaccines you get is much smaller than the number of different antigens you are exposed to. Considering the common cold alone, the incidence in the US is 6 per person year for children, 2 per person year for adults without exposure to children (see Cecil Medicine Ch. 369). Each of these exposures involves many different antigens. Vaccine related immune memory is a drop in the bucket.
answered 4 hours ago
De Novo
60211
edited 4 hours ago
answered 4 hours ago
De Novo
60211
answered 4 hours ago
De Novo
60211
answered 4 hours ago
De Novo
60211
60211
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